王惠，博士，青岛大学青年卓越人才

学习经历

2009.09-2013.06黑龙江中医药大学药学专业，本科

2013.09-2018.06沈阳药科大学药物分析学专业，博士，导师：郑江教授

工作经历

2018.08-2019.09美国范德堡大学(Vanderbilt University, Tennessee, USA）药学院生物化学中心，博士后研究员，合作导师：Prof. F. Peter Guengerich

2020.03月-至今 青岛大学药学院药物分析学系，讲师

主要研究方向

1.药物代谢活化及肝毒性机制研究

2.中药药效物质基础和作用机制研究

研究成果发表于药物代谢领域Drug Metab. Dispos.,Chem. Res. Toxicol.，J. Biol. Chem.等著名学术期刊，目前发表SCI学术论文十余篇，参编英文著作一部。

代表性论文和专著

(1)Wang, H^#.; Kang X. L^#.; Sun, S. W.; Yin, Y. C.; Jiang, K.; Tang G. D.; Tang X. N.; Wang, W. Discovery of pyrogallol thermal reaction products from a model process of roasting coffee beans as potent α-glucosidase inhibitors.Food Bioscience2022,46, 101583.

(2)Wang,H.; Wang, W. B.; Wang, Z. D.; Feng, Y. K.; Wang, S. J.; Peng, Y*.; Zheng, J*. Glutathione conjugation and protein adduction derived from oxidative debromination of benzbromarone in mice.Drug Metab. Dispos.2019,47(11), 1281-1290.

(3)Wang,H^#.;Yang, X. J^#.;Zheng, J*. Glutathione: Biosynthesis, Functions and Biological Implications (Chapter 9. Detection and Quantitation of GSH and GSSG),Nova Science Publishers, February2019.ISBN: 978-1-53614-740-7.https://novapublishers.com/shop/glutathione-biosynthesis-functions-and-biological-implications/

(4)Wang,H^#.; Peng, Y^#.; Zhang, T. J.; Lan, Q. S.; Zhao, H. M.; Wang, W. B.; Zhao, Y. F.; Wang, X.; Pang, J. X*.; Wang, S. J*.; Zheng, J*. Metabolic epoxidation is a critical step for the development of benzbromarone-induced hepatotoxicity.Drug Metab. Dispos.2017,45(12), 1354-1363.

(5)Wang,H.; Feng, Y. K.; Wang, Q.; Guo, X. C.; Huang, W. L.; Peng, Y*.; Zheng, J*. Cysteine-based protein adduction by epoxide-derived metabolite(s) of benzbromarone. Chem. Res. Toxicol.2016,29(12), 2145-2152.

(6)Wang, K^#.;Wang,H^#.; Peng, Y*.; Zheng, J*. Identification of epoxide-derived metabolite(s) of benzbromarone.Drug Metab. Dispos.2016,44(4), 607-615.

(7)Wang,H^#.;Wang, K^#.;Mao, X.;Zhang, Q. Q.;Yao, T.;Peng, Y*.;Zheng, J*. Mechanism-based inactivation of CYP2C9 by linderane.Xenobiotica2015,45(12), 1037-1046.

(8)Feng,Y.K.;Wang,H.;Wang,Q.;Huang,W.L.;Peng,Y*.;Zheng,J*.Chemical interaction of protein cysteine residues with reactive metabolites of methyleugenol.Chem.Res.Toxicol.2017,30(2), 564-573.

(9)Feng, Y. K.; Wang, S. D.;Wang,H.; Peng, Y*.; Zheng, J*. Urinary methyleugenol deoxyadenosine adduct as potential biomarker of methyleugenol exposure.J. Agric. Food Chem.2018,66(5), 1258-1263.

(10)Yang, X. J^#.; Feng, Y.K^#; Zhang, Z.;Wang,H.; Li, W.; Wang, D. O.; Peng, Y*.; Zheng, J*.In vitroandin vivoevidence for RNA adduction resulting from metabolic activation of methyleugenol.J. Agric. Food Chem.2020,68(51),15134-15141.

(11)Zhang, L. Q.; Zhang, X. M.; Zhang, H. W.*;Wang,H.; Xu, H.; Wang, F. M.; Lin, C.; Xiao, J.; Xu, W. Y. Multi-class and multi-residue screening of veterinary drugs and pesticides in infantformula using Quadrupole-Orbitrap MS with PRM scan mode. J. Mass Spectrom.2020,55(3): e4497.

(12)Ghodke, P. P^#.; Gonzalez-Vasquez, G^#.;Wang, H.; Johnson, K. M.; Sedgeman, C. A.; Guengerich, F. P*. Enzymatic bypass of anN⁶-deoxyadenosine DNA-ethylene dibromide-peptide cross-link by translesion DNA polymerases.J. Biol. Chem.2021,296: 100444.

(13)Zhao, K., Sun, S.,Wang, H., Wang, L., Qin, G., Fan, J., Guo, M., Wang, W*.α-Glucosidase inhibitory triterpenoids fromEuonymus fortunei.Bioorganic chemistry2021,111, 104980.

(14)Wang, J^#.; Sun, S. W^#.; Zhao, K.; Shi, H. L.; Fan, J. H.;Wang,H.; Liu, Y.; Liu, X. H.; Wang, W*. Insights into the inhibitory mechanism of purpurogallin on xanthine oxidase by multiple spectroscopic techniques and molecular docking.Journal of Molecular Structure2021,1228, 129772.

(15)Fan, J. H.; Sun, S. W.; Lv, C. Y.; Li, Z. Z.; Guo, M. R.; Yin, Y. C.;Wang, H.; Wang, W. Discovery of mycotoxin alternariol as a potential lead compound targeting xanthine oxidase.Chem Biol Interact.2022,360, 109948.

(16)Fan, J. H.; Lv, C. Y.; Li, Z. Z.; Guo, M. R.; Yin, Y. C.;Wang, H.; Wang, W.; Sun, S. W. α-Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ-G2.J Basic Microbiol.2022, doi: 10.1002/jobm.202200166.

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邮箱:huiwang@qdu.edu.cn; sara9025@163.com