王惠，博士，青岛大学副教授，硕士生导师

工作和学习经历

2025.01-至今青岛大学药学院，药物分析学系，副教授

2020.03-2024.12青岛大学药学院，药物分析学系，讲师/青年卓越

2018.08-2019.09美国范德堡大学(Vanderbilt University, Tennessee, USA）药学院生物化学中心，博士后研究员，合作导师：Prof. F. Peter Guengerich

2013.09-2018.06沈阳药科大学药物分析学专业，博士(硕博连读)，导师：郑江教授

2009.09-2013.06黑龙江中医药大学药学专业，学士

主要研究方向

1.药物代谢活化及肝毒性机制

2.中药药效物质基础和作用机制

主要从事细胞色素P450酶介导的药物代谢活化及其肝毒性机制研究，以及基于黄嘌呤氧化酶靶点治疗高尿酸血症的天然活性分子的发现和作用机制研究。研究成果发表于药物代谢领域以及食品科学领域Drug Metabolism andDisposition,Chemical Researchin Toxicology,Journal of Biological Chemistry,Food Bioscience等著名学术期刊，发表SCI学术论文二十余篇，参编英文著作一部，担任中草药英文版青年编委。

主持科研项目

1.国家自然科学基金青年项目（2024.01-2026.12），项目负责人

2.山东省自然科学基金青年项目（2022.01-2024.12），项目负责人

3.青岛市博士后创新项目（2023.01-2024.12），项目负责人

4.山东省中医药科技项目（2020.01-2021.12），项目负责人

代表性论文和专著

(1)Wang, H.; Xin, L.H.; Hou, P.Y.; Sun, S.W.; Zheng, J.; Wang, W*. Evidence for the metabolic activation of higenamine to quinone methide and ortho-quinone metabolites in vitro and in vivo using liquid chromatography tandem mass spectrometry.Journal of Pharmaceutical and Biomedical Analysis, 2025, 255, 116634.

(2)Xiao, H^#.;Wang, H^#.;Sun,S. W.;Ma,J. Y.;Wang,H.;Yin,Y. C.;Wang, W*.Identification of aurones and chalcones as the main contributors toxanthine oxidase inhibitory activity of snow chrysanthemum.Food Bioscience,2024,61,104650.

(3)Li, Z. Z^#.;Wang, H^#.; Sun, S. W.; Shao, Z. B.; Lv, C. Y.; Dong, X. Y.; Wang, L.; Wang, W*. Ellagitannins from pomegranate (Punica granatumL.) flower with xanthine oxidase andα-glucosidase inhibitory activities.Journal of Functional Foods,2024, 106153.

(4)Wang, H.;Zhang,H. W.;Zhang,X. M.;Yin,Y. C.;Ding,G. Q.;Tang,X. W.;Hou,P. Y.;Sun,S. W.;Wang, W*.Identification of coniferyl ferulate as the bioactive compound behind thexanthine oxidase inhibitory activity ofChuanxiong Rhizome.Journal of Functional Foods,2023,105378.

(5)Wang, H^#.; Kang X. L^#.; Sun, S. W.; Yin, Y. C.; Jiang, K.; Tang G. D.; Tang X. N.; Wang, W*. Discovery of pyrogallol thermal reaction products from a model process of roasting coffee beans as potentα-glucosidase inhibitors.Food Bioscience,2022,46, 101583.

(6) Ghodke, P. P^#.; Gonzalez-Vasquez, G^#.;Wang, H.; Johnson, K. M.; Sedgeman, C. A.; Guengerich, F. P*. Enzymatic bypass of anN⁶-deoxyadenosine DNA-ethylene dibromide-peptide cross-link by translesion DNA polymerases.Journalof Biological Chemistry,2021,296: 100444.

(7)Wang,H.; Wang, W. B.; Wang, Z. D.; Feng, Y. K.; Wang, S. J.; Peng, Y*.; Zheng, J*. Glutathione conjugation and protein adduction derived from oxidative debromination of benzbromarone in mice.Drug Metabolism andDisposition,2019,47(11), 1281-1290.

(8)Wang,H^#.;Yang, X. J^#.;Zheng, J*. Glutathione: Biosynthesis, Functions and Biological Implications (Chapter 9. Detection and Quantitation of GSH and GSSG),Nova Science Publishers, February2019.ISBN: 978-1-53614-740-7.https://novapublishers.com/shop/glutathione-biosynthesis-functions-and-biological-implications/

(9)Wang,H^#.;Peng, Y^#.;Zhang,T. J.;Lan,Q. S.;Zhao,H. M.;Wang,W. B.;Zhao,Y. F.;Wang,X.;Pang,J. X.*;Wang,S. J.*;Zheng, J*.Metabolicepoxidationis acriticalstep for thedevelopment ofbenzbromarone-inducedhepatotoxicity.Drug Metabolism andDisposition,2017 45(12),1354-1363.

(10)Wang, H.; Feng, Y.K.; Wang. Q.; Guo, X.C.; Huang. W.L.; Peng, Y*.; Zheng, J*. Cysteine-based protein adduction by epoxide-derived metabolite(s) of benzbromarone.Chemical Research in Toxicology, 2016, 29, 2145-2152.

(11)Wang, K^#.;Wang, H^#.; Peng, Y*.; Zheng, J*. Identification of epoxide-derived metabolite(s) of benzbromarone.Drug Metabolism and Disposition, 2016, 44, 607-615.

(12)Wang, H^#.; Wang, K^#.; Mao, X.; Zhang, Q.Q.; Yao, T.; Peng, Y*.; Zheng, J*. Mechanism-based inactivation of CYP2C9 by linderane.Xenobiotica, 2015, 45, 1037-1046.

联系方式

电话:15314258796

邮箱:sara9025@163.com;huiwang@qdu.edu.cn