论文整理

1. Li, N.; Han, S.; Ma, B.; Huang, X.; Xu, L.; Cao, J.; Sun, Y., Chemosensitivity enhanced by autophagy inhibition based on a polycationic nano-drug carrier. Nanoscale Adv 2021, 3(6), 1656-1673. DOI: 10.1039/d0na00990c.

2. Zeng, X.; Li, Z.; Zhu, C.; Xu, L.; Sun, Y.; Han, S., Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors. Drug Deliv 2021, 28(1), 2329-2347. DOI: 10.1080/10717544.2021.1995081.

3. Huang, X.; Han, S.; Chen, Z.; Zhao, L.; Wang, C.; Guo, Q.; Li, Y.; Sun, Y., Layered double hydroxide modified with deoxycholic and hyaluronic acids for efficient oral insulin absorption. Int J Nanomed 2021, 16, 7861-7873. DOI: 10.2147/IJN.S323381.

4. Gao, Y.; Ma, Q.; Cao, J.; Shi, Y.; Wang, J.; Ma, H.; Sun, Y.; Song, Y., Bifunctional alginate/chitosan stabilized perfluorohexane nanodroplets as smart vehicles for ultrasound and pH responsive delivery of anticancer agents. Int J Biol Macromol 2021, 191, 1068-1078. DOI: 10.1016/j.ijbiomac.2021.09.166.

5. Liu, L.; Ma, Q.; Cao, J.; Gao, Y.; Han, S.; Liang, Y.; Zhang, T.; Song, Y.; Sun, Y., Recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment. Cancer Nanotechnol 2021, 12(1), 1-31. DOI: 10.1186/s12645-021-00087-7.

6. Gao, Y.; Ma, Q.; Cao, J.; Wang, Y.; Yang, X.; Xu, Q.; Liang, Q.; Sun, Y., Recent advances in microfluidic-aided chitosan-based multifunctional materials for biomedical applications. Int J Pharmaceut 2021, 600, 120465. DOI: 10.1016/j.ijpharm.2021.120465

7. Shen, Z.; Ma, Q.; Zhou, X.; Zhang, G.; Hao, G.; Sun, Y.; Cao, J., Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment. Npg Asia Mater 2021, 13(1), 1-19. DOI: 10.1038/s41427-021-00303-1.

8. Xia, H.; Liang, Y.; Chen, K.; Guo, C.; Wang, M.; Cao, J.; Han, S.; Ma, Q.; Sun, Y.; He, B., Reduction-sensitive polymeric micelles as amplifying oxidative stress vehicles for enhanced antitumor therapy. Colloid Surface B 2021, 203, 111733. DOI: 10.1016/j.colsurfb.2021.111733.

9. Zhou, H.; Xu, P.; Sun, Y., Pharmacokinetics of abiraterone acetate released from a tablet based on lipid matrix in beagle dogs. Die Pharmazie-An International Journal of Pharmaceutical Sciences 2021, 76(7), 308-312. DOI: 10.1691/ph.2021.0171.

10. Li, Z.; Ning, F.; Wang, C.; Yu, H.; Ma, Q.; Sun, Y., Normalization of tumor microvasculature basing on targeting and modulation of tumor microenvironment. Nanoscale. 13, 17254-17271. DOI: 10.1039/d1nr03387.

11. Yan, J.; Zhan, X.; Zhang, Z.; Chen, K.; Wang, M.; Sun, Y.; He, B.; Liang, Y., Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects. J Nanobiotechnol 2021, 19(1), 1-16. DOI: 10.1186/s12951-021-01164-0.

12. Yan, J.; Zhang, Z.; Zhan, X.; Chen, K.; Pu, Y.; Liang, Y.; He, B., In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy. Nanoscale 2021, 13(21), 9577-9589. DOI: 10.1039/d1nr01155c.

13. Ding, X.; Geng, C.; Zhai, S.; Cao, X.; Shi, Z.; Liu, K., Development of laser ablation dielectric barrier discharge optical emission spectrometry (LA-DBD-OES) for direct determination of sulphur and chloride in the condensed phase and its application in pharmaceutical analysis. Analyst 2021, 146(24), 7537-7544. DOI: 10.1039/d1an01563j.

14. Qiao, Z.; Wei, N.; Jin, L.; Zhang, H.; Luo, J.; Zhang, Y.; Wang, K., The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus. Bioorg Chem 2021, 117, 105455. DOI: 10.1016/j.bioorg.2021.105455.

15. Qiao, Z.; Luo, J.; Tang, Y. Q.; Zhou, Q.; Qi, H.; Yin, Z.; Tang, X.; Zhu, W.; Zhang, Y.; Wei, N.; Wang, K., Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization. J Med Chem 2021, 64(21), 16282-16292. DOI: 10.1021/acs.jmedchem.1c01579.

16. Luo, J.; Zhang, H.; Guan, J.; An, B.; Peng, J.; Zhu, W.; Wei, N.; Zhang, Y., Detection of lipase activity in human serum based on a ratiometric fluorescent probe. New J Chem 2021, 45(21), 9561-9568. DOI: 10.1039/d1nj01155c.

17. Zhang, H.; Ju, Q.; Pang, S.; Wei, N.; Zhang, Y., Recent progress of fluorescent probes for the detection of alkaline phosphatase (ALP): A review. Dyes Pigments 2021, 194, 109569. DOI: 10.1016/j.dyepig.2021.109569.

18. Sun, S.; Zhao, W.; Li, Y.; Chi, Z.; Fang, X.; Wang, Q.; Han, Z.; Luan, Y., Design, synthesis and antitumor activity evaluation of novel HDAC inhibitors with tetrahydrobenzothiazole as the skeleton. Bioorg Chem 2021, 108, 104652. DOI: 10.1016/j.bioorg.2021.104652.

19. Wang, J.; Dong, L.; Liu, Y.; Chen, X.; Ma, Y.; Yin, H.; Du, S.; Qi, Y.; Wang, K., Efficient synthesis and oxidative folding studies of centipede toxin RhTx. Chinese J Org Chem 2021, 41(7), 2800-2809. DOI: 10.6023/cjoc202102045.

20. Chen, X. T.; Wang, J. Y.; Ma, Y. N.; Dong, L. Y.; Jia, S. X.; Yin, H.; Fu, X. Y.; Du, S. S.; Qi, Y. K.; Wang, K., DIC/Oxyma‐based accelerated synthesis and oxidative folding studies of centipede toxin RhTx. J Pept Sci 2022, 28(3), e3368. DOI: 10.1002/psc.3368.

21. Wang, J.; Dong, L.; Liu, Y.; Chen, X.; Ma, Y.; Yin, H.; Chi, Q.; Jia, S.; Du, S.; Qi, Y.; Wang, K., DIC/Oxyma Based Efficient Synthesis and Activity Evaluation of Spider Peptide Toxin GsMTx4. Chinese J Org Chem 2022, 42(2), 498-506. DOI: 10.6023/cjoc202109003.

22. Liang, S.; Hofman, K.; Friedrich, M.; Keller, J.; Manolikakes, G. Recent Progress and Emerging Technologies towards a sustainable synthesis of sulfones. Chem Sus Chem 2021, 14(22), 4878-4902. DOI: 10.1002/cssc.202101635.

23. Li, F.; Liang, S.; Luan, Y.; Chen, X.; Zhao, H.; Huang, A.; Li, P.; Li, W., Organocatalytic regio-, diastereo-and enantioselective γ-additions of isoxazol-5 (4 H)-ones to β, γ-alkynyl-α-imino esters for the synthesis of axially chiral tetrasubstituted α-amino allenoates. Org Chem Front 2021, 8(6), 1243-1248. DOI: 10.1039/d0qo01505a.

24. Li, F.; Yang, Z.; Yang, Y.; Huang, Q.; Chen, X.; Li, P.; Dong, M.; Li, W., Organocatalytic Enantioselective Aza‐Michael Addition of Arylamines to 7‐Methide‐7H‐Indoles. Adv Synth Catal 2021, 363(10), 2557-2561. DOI: 10.1002/adsc.202100039.

25. Wang, Z.; Lin, X.; Chen, X.; Li, P.; Li, W., Organocatalytic stereoselective 1, 6-addition of thiolacetic acids to alkynyl indole imine methides: access to axially chiral sulfur-containing tetrasubstituted allenes. Org Chem Front 2021, 8(13), 3469-3474. DOI: 10.1039/d1qo00394a.

26. Lin, X.; Ge, K.; He, N.; Chen, X.; Li, P.; Dong, M.; Li, W., Organocatalytic enantioselective construction of acyclic N, N‐acetals via aza‐addition of arylamines to ketimines. Adv Synth Catal 2021, 363(18), 4332-4337. DOI: 10.1002/adsc.202100600.

27. Wu, Y.; Yue, Z.; Qian, C.; Chen, X.; Li, F.; Li, P.; Li, W., Organocatalytic enantioselective construction of axially chiral tetrasubstituted allenes via 1, 6‐addition of alkynyl indole imine methides with 2‐substituted indoles. Asian J Org Chem 2022, 11(3), e202100724. DOI: 10.1002/ajoc.202100724.

28. Lv, M.; Wu, H.; Qu, Y.; Wu, S.; Wang, J.; Wang, C.; Luan, Y.; Zhang, Z., The design and synthesis of transient receptor potential vanilloid 3 inhibitors with novel skeleton. Bioorg Chem 2021, 114, 105115. DOI: 10.1016/j.bioorg.2021.105115.

29. Wang, J.; Lv, M.; Xia, H.; Du, J.; Zhao, Y.; Li, H.; Zhang, Z., Minimalist design for a hand-held SARS-Cov-2 sensor: peptide-induced covalent assembly of hydrogel enabling facile fiber-optic detection of a virus marker protein. ACS Sensors 2021, 6(6), 2465-2471. DOI: 10.1021/acssensors.1c00869.

30. Peng, X.; Sun, F.; Li, G.; Wang, C.; Zhang, Y.; Wu, C.; Zhang, C.; Sun, Y.; Wu, S.; Zhang, Y.; Zong, H.; Guo, R.; Lou, H., New xanthones with antiagricultural fungal pathogen activities from the endophytic fungus diaporthe goulteri L17. J Agr Food Chem 2021, 69(38), 11216-11224. DOI: 10.1021/acs.jafc.1c03513.

31. Qi, H.; Shi, Y.; Wu, H.; Niu, C.; Sun, X.; Wang, K., Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus. Acta Pharm Sin B 2022, 12(2), 723-734. DOI: 10.1016/j.apsb.2021.08.002.

32. Tian, C.; Gao, H.; Peng, X. P.; Li, G.; Lou, H. X., Fusidic acid derivatives from the endophytic fungus Acremonium pilosum F47. Journal of Asian Natural Products Research 2021, 23(12), 1148-1155. DOI: 10.1080/10286020.2020.1866559.

33. Chuan, T. I. A. N.; Ke, W. A. N. G.; Zhang, X., Gang, L. I., & Hong-Xiang, L. O. U., Old fusidane-type antibiotics for new challenges: Chemistry and biology. Chin J Nat Medicines 2022, 20(2), 81-101. DOI: 10.1016/S1875-5364(21)60114-0.

34. Li, G.; Lin, P.; Wang, K.; Gu, C. C.; Kusari, S., Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms. Trends Cancer 2022, 8(1), 65-80. DOI: 10.1016/j.trecan.2021.10.002.

35. Zhao, K.; Sun, S.; Wang, H.; Wang, L.; Qin, G.; Fan, J.; Guo, M.; Wang, W., α-Glucosidase inhibitory triterpenoids from Euonymus fortunei. Bioorg Chem 2021, 111, 104980. DOI: 10.1016/j.bioorg.2021.104980.

36. Liu, X.; Liu, Y.; Wang, X.; Wang, T.; Sun, S.; Wang, W., Study on the molecular structure and chemical properties of the polyoxypregnane derivatives 11α-O-2-methylbutyryl-12β-O-tigloyl tenacigenin B and 11α, 12β-O-ditigloyl tenacigenin B by combining experimental and theoretical methods. J Mol Struct 2021, 1237, 130350. DOI: 10.1016/j.molstruc.2021.130350.

37. Wang, J.; Sun, S.; Zhao, K.; Shi, H.; Fan, J.; Wang, H.; Liu, Y.; Liu, X.; Wang, W., Insights into the inhibitory mechanism of purpurogallin on xanthine oxidase by multiple spectroscopic techniques and molecular docking. J Mol Struct 2021, 1228, 129772. DOI: 10.1016/j.molstruc.2020.129772.

38. Sui, S.; Yu, H.; Wang, X.; Wang, W.; Yang, X.; Pan, X.; Zhou, Q.; Xin, C.; Du, R.; Wu, S.; Zhang, J.; Cao, Q.; Wang, N.; Kuehn, M. H.; Zhu, W., iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma. Invest Ophth Vis Sci2021, 62(10), 28-28. DOI: 10.1167/iovs.62.10.28.

39. Zhu, W.; Hou, F.; Fang, J.; Fard, M. R. B.; Liu, Y.; Ren, S.; Wu, S.; Qi, Y.; Sui, S.; Read, A. T.; Sherwood, J. M.; Zou, W.; Yu, H.; Zhang, J.; Overby, D. R.; Wang, N.; Ethier, C. R.; Wang, K., The role of Piezo1 in conventional aqueous humor outflow dynamics. Iscience 2021, 24(2), 102042. DOI: 10.1016/j.isci.2021.102042.

40. Wang, W.; Miao, Y.; Sui, S.; Wang, Y.; Wu, S.; Cao, Q.; Duan, H.; Qi, X.; Zhou, Q.; Pan, X.; Zhang, J.; Chen, X.; Han, Y.; Wang, N.; Kuehn, M. H.; Zhu, W., Xeno-and feeder-free differentiation of human iPSCs to trabecular meshwork-like cells by recombinant cytokines. Ransl Vis Sci Techn 2021, 10(6), 27-27. DOI: 10.1167/tvst.10.6.27.

41. Fang, J.; Hou, F.; Wu, S.; Liu, Y.; Wang, L.; Zhang, J.; Wang, N.; Wang, K.; Zhu, W., Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice. Mol Vis 2021, 27, 354-364. DOI: PMC8219506.

42. Li, H.; Gao, J.; Chang, Y.; Li, K.; Wang, L.; Ju, C.; Zhang, F., JWX-A0108, a positive allosteric modulator of α7 nAChR, attenuates cognitive deficits in APP/PS1 mice by suppressing NF-κB-mediated inflammation. Int Immunopharmacol 2021, 96, 107726. DOI: 10.1016/j.intimp.2021.107726.

43. Zhang, C.; Li, H.; Gao, J.; Cui, X.; Yang, S.; Liu, Z., Prognostic significance of ANO1 expression in cancers. Medicine 2021, 100(4). DOI: 10.1097/MD.0000000000024525.

44. Wei, N.; Chu, Y.; Liu, H.; Xu, Q.; Jiang, T.; Yu, R., Antagonistic mechanism of α-conotoxin BuIA toward the human α3β2 nicotinic acetylcholine receptor. ACS Chem Neurosci 2021, 12(24), 4535-4545. DOI: 10.1021/acschemneuro.1c00568.

45. Hou, X.; Zhang, C.; Wang, L.; Wang, K., Natural piperine improves lipid metabolic profile of high-fat diet-fed mice by upregulating SR-B1 and ABCG8 transporters. J Nat Prod 2021, 84(2), 373-381. DOI: 10.1021/acs.jnatprod.0c01018.

46. Hou, X.; Malainer, C.; Atanasov, A. G.; Heiß, E. H.; Dirsch, V. M.; Wang, L.; Wang, K., Evodiamine lowers blood lipids by up-regulating the PPARγ/ABCG1 pathway in high-fat-diet-fed mice. J Nat Prod 2021, 84(12), 3110-3116. DOI: 10.1021/acs.jnatprod.1c00881.

47. Nie, Y.; Li, Y.; Liu, L.; Ren, S.; Tian, Y.; Yang, F., Molecular mechanism underlying modulation of TRPV1 heat activation by polyols. J Biol Chem 2021, 297(1), 1-21. DOI: 10.1016/j.jbc.2021.100806.

48. Li, Y.; Chen, X.; Nie, Y.; Tian, Y.; Xiao, X.; Yang, F., Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin. J Biol Chem 2021, 297(3), 1-18. DOI: 10.1016/j.jbc.2021.101022.

49. Song, Z.; Wang, J. H., miRNA and mRNA profiles in ventral tegmental area from juvenile mice with companion communication of improving CUMS-induced depression-like behaviors. Front Psychiatry 2021, 12, 417, 1-12. DOI: 10.3389/fpsyt.2021.634933.

50. Zhang, L.; Lu, W.; Lu, C.; Guo, Y.; Chen, X.; Chen, J.; Xu, F; Wan, H.; Dong, H., Beneficial effect of capsaicin via TRPV4/EDH signals on mesenteric arterioles of normal and colitis mice. J Adv Res 2021, 1-13. DOI: 10.1016/j.jare.2021.11.001.

51. Niu, H. L.; Liu, Y. N.; Xue, D. Q.; Dong, L. Y.; Liu, H. J.; Wang, J.; Zheng, Y. L.; Zou. A. R.; Shao, L. M.; Wang, K., Inhibition of Nav1. 7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain. Acta Pharmacol Sin 2021, 42(8), 1235-1247. DOI: 10.1038/s41401-021-00682-9.

52. Liu, Y.; Liu, Z.; Wang, K., The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?. Acta Pharm Sin B 2021, 11(6), 1412-1433. DOI: 10.1016/j.apsb.2020.12.003.

53. Wang, J.; Liu, Y.; Hu, F.; Yang, J.; Guo, X.; Hou, X.; Ju, C; Wang, K., Activation of neuronal voltage-gated potassium Kv7/KCNQ/M-current by a novel channel opener SCR2682 for alleviation of chronic pain. J Pharmacol Exp Ther 2021, 377(1), 20-28. DOI: 10.1124/jpet.120.000357.

54. Priyadharsini, R. P., Novel anticancer drugs approved in 2020. BioMed Res J 2021, 5(3), 475-479. DOI: 10.5582/ddt.2021.01013.

55. Hu, F.; Cao, X.; Niu, C.; Wang, K., Co-assembly of warm-temperature sensitive TRPV3 and TRPV4 channel complexes with distinct functional properties. Mol Pharmacol 2022, 1-51. DOI: 10.1124/molpharm.121.000370.

56. Yuan, Y.; Zhou, J.; Hu, R.; Zou, L.; Ji, L.; Jiang, G., Piperine protects against pancreatic β-cell dysfunction by alleviating macrophage inflammation in obese mice. Life Sci 2021, 274, 119312. DOI: 10.1016/j.lfs.2021.119312.

57. Pang, X.; Zhang, X.; Jiang, Y.; Su, Q.; Li, Q.; Li, Z., Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer. Biomolecules 2021, 11(2), 135. DOI: 10.3390/biom11020135.

58. Wang, M.; Liang, Y.; Chen, K.; Wang, M.; Long, X.; Liu, H.; Sun, Y.; He, B., The management of diabetes mellitus by mangiferin: Advances and Prospects. Nanoscale 2021, 14, 2119-2135. DOI: 10.1039/d1nr06690k.

59. Wu, H.; Niu, C.; Qu, Y.; Sun, X.; Wang, K., Selective activation of TRPA1 ion channels by nitrobenzene skin sensitizers DNFB and DNCB. J Biol Chem 2022, 298(2), 101555. DOI: 10.1016/j.jbc.2021.101555.

60. Zhou, J.; Zou, L.; Zhang, X.; Ji, L.; Nezhad, P. D. K., Computational investigation of sensing properties of Ca-doped zinc oxide nanotube toward formaldehyde. J Mol Model 2021, 27(10), 1-8. DOI: 10.1007/s00894-021-04921-y.