王惠，博士，青岛大学青年卓越人才

学习经历

2009.09-2013.06黑龙江中医药大学药学专业，学士

2013.09-2018.06沈阳药科大学药物分析学专业，博士(硕博连读)，导师：郑江教授

工作经历

2018.08-2019.09美国范德堡大学(Vanderbilt University, Tennessee, USA）药学院生物化学中心，博士后研究员，合作导师：Prof. F. Peter Guengerich

2020.03月-至今 青岛大学药学院药物分析学系

主要研究方向

1.药物代谢活化及肝毒性机制

2.中药药效物质基础和作用机制

研究成果发表于药物代谢领域以及食品科学领域Drug Metabolism andDisposition,Chemical Researchin Toxicology,Journal of Biological Chemistry,Food Bioscience等著名学术期刊，目前发表SCI学术论文十余篇，参编英文著作一部。主持国家自然科学基金项目、山东省自然科学基金项目、山东省中医药科技项目和青岛市博士后创新项目各1项。

代表性论文和专著

(1)Xiao, H^#.;Wang, H^#.;Sun,S. W.;Ma,J. Y.;Wang,H.;Yin,Y. C.;Wang, W.Identification of aurones and chalcones as the main contributors toxanthine oxidase inhibitory activity of snow chrysanthemum.Food Bioscience,2024,61,104650.

(2)Li, Z. Z^#.;Wang, H^#.; Sun, S. W.; Shao, Z. B.; Lv, C. Y.; Dong, X. Y.; Wang, L.; Wang, W. Ellagitannins from pomegranate (Punica granatumL.) flower with xanthine oxidase andα-glucosidase inhibitory activities.Journal of Functional Foods,2024, 106153.

(3)Wang, H.;Zhang,H. W.;Zhang,X. M.;Yin,Y. C.;Ding,G. Q.;Tang,X. W.;Hou,P. Y.;Sun,S. W.;Wang, W.Identification of coniferyl ferulate as the bioactive compound behind thexanthine oxidase inhibitory activity ofChuanxiong Rhizome.Journal of Functional Foods,2023,105378.

(4)Wang, H^#.; Kang X. L^#.; Sun, S. W.; Yin, Y. C.; Jiang, K.; Tang G. D.; Tang X. N.; Wang, W. Discovery of pyrogallol thermal reaction products from a model process of roasting coffee beans as potentα-glucosidase inhibitors.Food Bioscience,2022,46, 101583.

(5) Ghodke, P. P^#.; Gonzalez-Vasquez, G^#.;Wang, H.; Johnson, K. M.; Sedgeman, C. A.; Guengerich, F. P*. Enzymatic bypass of anN⁶-deoxyadenosine DNA-ethylene dibromide-peptide cross-link by translesion DNA polymerases.Journalof Biological Chemistry,2021,296: 100444.

(6)Wang,H.; Wang, W. B.; Wang, Z. D.; Feng, Y. K.; Wang, S. J.; Peng, Y*.; Zheng, J*. Glutathione conjugation and protein adduction derived from oxidative debromination of benzbromarone in mice.Drug Metabolism andDisposition,2019,47(11), 1281-1290.

(7)Wang,H^#.;Yang, X. J^#.;Zheng, J*. Glutathione: Biosynthesis, Functions and Biological Implications (Chapter 9. Detection and Quantitation of GSH and GSSG),Nova Science Publishers, February2019.ISBN: 978-1-53614-740-7.https://novapublishers.com/shop/glutathione-biosynthesis-functions-and-biological-implications/

(8)Wang,H^#.;Peng, Y^#.;Zhang,T. J.;Lan,Q. S.;Zhao,H. M.;Wang,W. B.;Zhao,Y. F.;Wang,X.;Pang,J. X.;Wang,S. J.;Zheng, J.Metabolicepoxidationis acriticalstep for thedevelopment ofbenzbromarone-inducedhepatotoxicity.Drug Metabolism andDisposition,201745(12),1354-1363.

电话:15314258796

邮箱:huiwang@qdu.edu.cn; sara9025@163.com