卫宁宁，副教授，硕士生导师

个人简介：

卫宁宁长期专注于药用植物的活性分子、毒素对离子通道的药理学评价及分子机制研究、小分子化合物对离子通道的光控调节；博士毕业于北京大学基础医学院，主持国家自然科学青年基金、山东省自然科学博士基金和面上基金、中国博士后科学基金面上项目等多项基金；以第一作者或通讯作者在Nat Commun、J Med Chem、Anal Chem、J Biol Chem等杂志上发表过文章，共发表SCI论文30余篇。近年来指导本科生参加竞赛，获得第十五届全国大学生药苑论坛创新二等奖、在第七届/第八届全国医药院校药学/中药学专业大学生实验技能大赛、山东省大学生医药生物技术技能大赛多次获奖。

研究方向：

药用植物的活性分子、毒素对离子通道的药理学评价及分子机制研究

小分子化合物对离子通道的光控调节

筛选镇痛、抗癫痫、抗肥胖相关的化合物并进行药理学评价

代表性研究成果：

1.Nan Yang, Zhen Qiao, Qiqi Zhou, Xiuying Chang, Chaoyue Sun, Yanru Zhang*, Ningning Wei* and KeWei Wang, Discovery of non-electrophilic TRPA1 channel agonists with anti-nociceptive effects via rapid current desensitization. European Journal of Medicinal Chemistry, 2025, Doi: 10.1016/j.ejmech.2025.117586

2.Hongbin Wang, Zhen Qiao, Kun Luan, Wei Xiang, Xiuying Chang, Yanru Zhang, Ningning Wei, KeWei Wang, Identification of a new retigabine derivative with improved photostability for selective activation of neuronal Kv7 channels and antiseizure activity, Epilepsia, 2024, 65:2923-2934.

3.Qikai Ju, Zhen Qiao, Ningning Wei*, Yanru Zhang*, A super-fast response fluorescent probe for detecting endogenous H2S in living cells, 2023, Dyes and Pigments, 19 (2023) 111518.

4. Hongyi Zhang, Jiajie Luo, Zhen Qiao, Baoshuai An, Ningning Wei*, Yanru Zhang*,An activatable probe for visualization of DAGL activity in hippocampal tissue of brain-injured mice,2022,Sensors and Actuators B-Chemical, 367 (2022) 132047.

5. Zhen Qiao, Jiajie Luo, Yi-Quan Tang, Qiqi Zhou, Hang Qi, Zhengji Yin, Xiaowen Tang, Wei Zhu, Yanru Zhang*, Ningning Wei*, and KeWei Wang, Photosensitive and photoswitchable TRPA1 agonists optically control pain through channel desensitization, 2021, Journal of Medicinal Chemistry, 64, 16282−16292.

6. Zhen Qiao, Hang Qi, Hongyi Zhang, Qiqi Zhou, Ningning Wei,* Yanru Zhang,* and KeWei Wang, Visualizing TRPA1 in the Plasma Membrane for Rapidly Screening Optical Control Agonists via a Photochromic Ligand Based Fluorescent Probe, Analytical Chemistry, 2020, 92:1934-1939.

7. Shilong Yang#, Fan Yang#, Ningning Wei#, Jing Hong, Bowen Li, Lei Luo, Mingqiang Rong, Vladimir Yarov-Yarovoy, Jie Zheng*, KeWei Wang*, Ren Lai*, A pain-Inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1, Nature Communications, 2015, 6: 8297.

联系方式：weiningning@qdu.edu.cn