刘佳，男，1981年出生，博士，讲师，硕士生导师，副教授，2015年入选青岛大学第三层次特聘教授人才计划；2014年毕业于中科院海洋研究所，期间获得国家公派留学奖学金，赴美国哈佛医学院学习1年；2014年进入青岛大学医学部工作。首次发现了肌细胞增强因子MEF2D在肝癌中的作用，明确了MEF2D在临床诊断和预后中的应用价值，阐明了MEF2D参与肝癌发生发展的分子机制，并以共同第一作者的身份将研究成果发表(Ma et al. Cancer Res. 2014)；

 现主持国家自然科学基金1项，山东省自然科学基金1项，国家博士后科学基金1项，青岛市博士后应用项目1项，参与国家863课题和国家自然科学基金重大国际合作课题等国家级科研项目8项；发表SCI论文30篇，影响因子累计145.035，单篇论文引用次数最高达到113 次，其中以第一作者（含共同第一作者）或通讯作者身份在Cancer Research（影响因子9.329）等杂志发表SCI论文15篇，累计影响因子58.803；申请国家发明专利2项（均为第1完成人）；获2014年度中国科学院院长优秀奖；任Translational Cancer Research 编委，PLoS ONE，Tumor Biology，Human Gene Therapy Methods，Molecular and Cellular Biochemistry, Oncology Letters杂志审稿人。

研究方向

1.       肌细胞增强因子MEF2家族蛋白在肿瘤中的作用以及作为治疗靶点或诊断标记的应用研究

2.       非编码RNA在肿瘤中的作用以及作为治疗靶点或诊断标记的应用研究

3.       使用CRISPR/Cas9和Argonaute技术建立肿瘤的转基因动物模型

4.       肿瘤免疫治疗技术的研发

5.       使用噬菌体展示技术寻找高亲和力的单克隆抗体

6.       新型分子生物技术的探索和开发。

全部发表论文(^#第一作者，*通讯作者)：

1.        Jun Wang, Zeng-jie Lei, Yan Guo, Tao Wang, Zhong-yi Qin, Hua-liang Xiao, Li-lin Fan, Dong-feng Chen, Xiu-wuBian, Jia Liu*, Bin Wang*.miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells.Oncotarget.2015 Nov 10;6(35):37852-70.(*通讯作者)(IF: 6.359)

2.        Leina Ma^#, Jia Liu^#, Limei Liu, GuangjieDuan, Qingliang Wang, YanminXu, Feng Xia, Juanjuan Shan, JunjieShen, Zhi Yang, Ping Bie, Youhong Cui, Xiu-wuBian, Jesus Prieto, Matías A. Avila, Cheng Qian^*. Overexpression of the Transcription Factor MEF2D in HepatocelullarCarcinoma Sustains Malignant Character by Suppressing G₂-M Transition Genes. Cancer Res. 2014 Mar 1, 74(5):1452-1462. (^#共同第一作者)(IF: 9.329)ISSN: 0008-5472

3.        Jia Liu^#, ShavaliShaik^#, Xiangpeng Dai, Qiong Wu, Xiuxia Zhou, Zhiwei Wang^*, Wenyi Wei^*. Targeting the ubiquitin pathway for cancer treatment. BiochimBiophysActa-Reviews on Cancer.2015 Jan, 1855(1):50-60. Review. (^#共同第一作者)(IF:7.845)ISSN: 0304-419X

4.        Jia Liu^#, Leina Ma^#, Caixin Li, Ziyu Zhang, Guanghua Yang^*, Wenwei Zhang^*. Tumor-targeting TRAIL expression mediated by miRNA response elements suppressed growth of uveal melanoma cells. MolOncol. 2013 Dec, 7(6):1043-1055. (^#共同第一作者)(IF: 5.935)ISSN: 1574-7891

5.        Jia Liu^#, LanhongZheng^#, Leina Ma^#, Bin Wang, Youguang Zhao, Ning Wu, Ge Liu, Xiukun Lin^*. Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy. J NutrBiochem. 2014 Nov, 25(11):1154-1160. (^#共同第一作者)(IF: 3.794)ISSN: 0955-2863

6.        Xiaoping He^#,Jia Liu^#, Chunyan Yang^#, Changqing Su, Chengliang Zhou, Qi Zhang, Linfang Li, Hongping Wu, Xinyuan Liu, Mengchao Wu, QijunQian^*. 5/35 Fiber-Modified Conditionally Replicative Adenovirus Armed with p53 Shows Increased Tumor-Suppressing Capacity to Breast Cancer Cells. Human Gene Ther. 2011 Mar, 22(3):283-292. (^#共同第一作者)(IF:4.218)ISSN: 1043-0342

7.        Bin Wang^#, Jia Liu^#, Leina Ma, Hualiang Xiao, Yazhou Wang, Yan Li, Zhe Wang, Linli Fan, Chunhui Lan, Min Yang, Lu Hu, Yanlin Wei, Xiu Wu Bian, Dongfeng Chen, Jun Wang^*. Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44+ gastric cancer cells via attenuating Wnt signaling. J Gastroenterol. 2013 Jul,  48(7):798-808.(^#共同第一作者)(IF:4.02) ISSN: 0944-1174

8.        Liu J^#, Ma L^#, Chen X, Wang J, Yu T, Gong Y, Ma A, Zheng L^*, Liang H^*. ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway. Tumor Biol. 2015 Dec 29. [Epub ahead of print] (^#共同第一作者)(IF: 3.611) ISSN: 1010-4283

9.        Jia Liu^#, Ning Wu^#, Leina Ma, Ming Liu, Ge Liu, Yuyan Zhang, Xiukun Lin^*. Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms. PLoS ONE. 2014 Mar 13, 9(3):e91606. (^#共同第一作者)(IF: 3.234)ISSN: 1932-6203

10.    Jia Liu^#, Leina Ma^#, Ning Wu, Ge Liu, LanhongZheng^*, Xiukun Lin^*. Aplysin Sensitizes Cancer Cells to TRAIL by Suppressing P38 MAPK/Survivin Pathway. Mar Drugs. 2014 Sep 25, 12(9):5072-5588. (^#共同第一作者)(IF:2.853)ISSN: 1660-3397

11.    Jia Liu^#, LanhongZheng^#, Ning Wu^#, Leina Ma, JiatengZhong, Ge Liu, Xiukun Lin^*. Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway. J Agr Food Chem. 2014, 62(24):5528-5537. (^#共同第一作者)(IF: 2.912)ISSN: 0021-8561

12.     Jia Liu^#, LanhongZheng^#, JiatengZhong^#, Ning Wu, Ge Liu, Xiukun Lin^*. Oleanolic acid induces protective autophagy in cancer cells through JNK and mTOR pathways. Oncol Rep. 2014 Aug 5, 32(2):567-572. (^#共同第一作者) (IF: 2.301) ISSN: 1021-335X

13.     Jia Liu^#, Ning Wu^#, Leina Ma, JiatengZhong, Ge Liu, LanhongZheng^*, Xiukun Lin^*. p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid. Asian Pac J Cancer Prev. 2014 June, 15(11):4519-4525. (^#共同第一作者)(IF: 1.5)ISSN: 1513-7368(不再是SCI)

14.    Jia Liu, Leina Ma, Yigang Wang, Xinyuan Liu and Qijun Qian. A novel strategy for cancer treatment: targeting cancer stem cells. Chin Sci Bull. 2008, 53(12): 1777-1783. Review. (^#共同第一作者) (IF:0.683)

15.    刘佳, 瞿存业, 马蕾娜, 石文芳, 钱其军^*. YB-1与肿瘤发生及治疗. 生物化学与生物物理进展. 2008, 35(7): 744-750.(IF:0.211)

16.    Wu N, Liu J, Zhao X, Yan Z, Jiang B, Wang L, Cao S, Shi D,Lin X.Crdamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells.Tumor Biol.2015 Dec, 36(12):9667-76. (IF: 3.611) ISSN: 1010-4283

17.    Juanjuan Shan, JunjieShen, Limei Liu, Feng Xia, ChuanXu, GuangjieDuan, YanminXu, Qinghua Ma, Zhi Yang, Qianzhen Zhang, Leina Ma, Jia Liu, SenlinXu, Xiaochu Yan, Ping Bie, Youhong Cui, Xiu-wuBian, Cheng Qian. Nanog regulates self-renewal of cancer stem cell through the insulin-like growth factor pathway in human hepatocellular carcinoma. Hepatology. 2012 Sep, 56(3):1004-1014.(IF:12.003)ISSN: 0270-9139

18.    Ning Wu, Xiukun Lin^*, Xiangdong Zhao, LanhongZheng, Lin Xiao, Jia Liu, Ge Liu, Shousong Cao^*. MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways. Br J Cancer. 2013 Nov 26; 109(11):2853-2863.(IF:4.817)ISSN: 0007-0920

19.    Wenjia Lou, Qing Chen, Leina Ma, Jia Liu, Zhi Yang, JunjieShen, Youhong Cui, Xiu-wuBian, Cheng Qian^*. Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model. J Mol Med (Berl). 2013 Jun. 91(6):715-725.(IF: 4.739) ISSN: 0946-2716

20.    YanminXu^#, Feng Xia^#, Leina Ma, Juanjuan Shan, JunjieShen, Zhi Yang, Jia Liu, Yonghong Cui, XiuwuBian, Ping Bie^*, Cheng Qian^*. MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest. Cancer Lett.2011 Nov 28, 310(2): 160-169.(IF:4.238)ISSN: 0304-3835

21.    Wu N, Liu J, Zhao X, Yan Z, Jiang B, Wang L, Cao S, Shi D, Lin X.Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells.Tumor Biol. 2015 Dec;36(12):9667-76. (IF:3.611) ISSN: 1010-4283

22.    Zheng L, Yi Y, Liu J, Lin X, Yang K, Lv M, Zhou X, Hao J, Liu J, Zheng Y, Sun M. Isolation and Characterization of Marine Brevibacillus sp. S-1 Collected from South China Sea and a Novel Antitumor Peptide Produced by the Strain. PLoS One.2014 Nov 5;9(11):e111270.(IF: 3.534)ISSN: 1932-6203

23.    Lin Zhang, Gang Huang, Xiaowu Li, Yujun Zhang, Yan Jiang, JunjieShen, Jia Liu, Qingliang Wang, Jin Zhu, XiaobinFeng, Jiahong Dong^*and Cheng Qian^*. Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor-1a in hepatocellular carcinoma. BMC cancer. 2013 Mar 9. 13:108.(IF:3.319)ISSN: 1471-2407

24.    Feng-xia Wang, Ning Wu, Jian-teng Wei, Jia Liu, Jin Zhao, Ai-guoJi and Xiu-kun Lin. A novel protein from Eupolyphagasinensis inhibits adhesion, migration, and invasion of human lung cancer A549 cells. Biochem Cell Biol. 2013Aug. 91(4): 244-251.(IF:2.35) ISSN: 0829-8211

25.    Leina Ma, Jia Liu, JunjieShen, Li Liu, Jia Wu, Wei Li, JingjingLuo, Qing Chen and Cheng Qian^*. Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. Cancer BiolTher. 2010 Apr 1, 9(7): 554-561.(IF:2.907)ISSN: 1538-4047

26.    Chunbao Li, Qianpeng Cheng, Jia Liu, Bin Wang, Dongfeng Chen, Yujie Liu. Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma. Mol Cell Biochem. 2012 May, 364(1-2): 337-344.(IF:2.329)ISSN: 0300-8177

27.    Leina Ma, Jia Liu,Xinling Zhang, Qi J, Wengong Yu, YuchaoGu. p38 MAPK-dependent Nrf2 induction enhances the resistance of glioma cells against TMZ. Med Oncol.2015 Mar, 32(3):69. (IF: 2.634)

28.    Leina Ma, Jia Liu,Cuifang Han, TingtingZhuang, Qingjuan Wang, Wengong Yu, YuchaoGu. Eugenol protects cells against hydrogen peroxide-induced oxidative stress via Nrf2. ExpTher Med. 2015 Accepted. (IF: 1.269)

29.    Guanghua Yang, Shuqi Wang, Huilin Wei, Jian Ping, Jia Liu, Lieming Xu, Wenwei Zhang. Patch oligodeoxynucleotide synthesis (POS): a novel method for synthesis of long DNA sequences and full-length genes. BiotechnolLett. 2012 Apr, 34(4):721-728.(IF:1.853)ISSN: 0141-5492

30.    Wang JX, Zhang XJ, Li Q, Wang K, Wang Y, Jiao JQ, Feng C, Teng S, Zhou LY, Gong Y, Zhou ZX, Liu J, Wang JL, Li PF. MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD.Circ Res.2015 Jul 31;117(4):352-363. (IF: 11.019)ISSN: 0009-7330

31.    Wang JX, Gao J, Ding SL, Wang K, Jiao JQ, Wang Y, Sun T, Zhou LY, Long B, Zhang XJ, Li Q, Liu JP, Feng C, Liu J, Gong Y, Zhou Z, Li PF. Oxidative Modification of miR-184 Enables It to Target Bcl-xL and Bcl-w. Mol Cell. 2015 Jul 2;59(1):50-61.(IF: 14.018) ISSN: 1097-2765

32.    Wang K, Long B, Liu F, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong YH, Li N, Li PF. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J. 2016 Jan 21. pii: ehv713. [Epub ahead of print] (IF: 15.203) ISSN: 0195-668X

33.    李林芳, 胡还章, 刘辰, 王敬晗, 吴红平, 金华君, 苏长青, 姜小清, 刘佳, 顾坚忠, 吴孟超, 钱其军. 首株来源于转移灶的人胆囊癌细胞系EH-GB1的建立及鉴定. 中华肿瘤杂志. 2010, 32(2): 84-87.

34.    钱其军, 刘佳,吴孟超. 肿瘤干细胞: 起源与争论. 中国肿瘤生物治疗杂志. 2007. 14(6): 501-504.

35.    李伟, 刘佳,刘立. 肿瘤基因治疗中腺病毒载体改造热点.中国生物化学与分子生物学报. 2008, 24(11): 1008-1013.

36.    马蕾娜, 刘佳,钱其军. 携带5/35嵌合型fiber的溶瘤腺病毒对胃癌细胞的杀伤能力研究. 浙江理工大学学报. 2008, 25(5): 564-568.

37.    杨春燕, 刘佳,钱其军. 一种新型的Tet-off慢病毒调控系统的构建及其调控作用. 浙江理工大学学报. 2010, 27(5): 805-809.

发明专利（申请中）

1. 一种高效表达抗癌基因的受特定miRNA调控的在胶质瘤细胞中特异增殖的腺病毒及其用途（申请号201210329533.；申请公布号:CN103667347A）刘佳，马蕾娜，郭国财。

2. 一种诱导肿瘤细胞凋亡的方法（申请号201510869552.0）刘佳，马蕾娜，陈潇。