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李文军
发布时间:2018-10-12    作者:    点击:[]

李文军博士

男,1984年3月出生,青岛大学特聘教授,泰山学者青年专家,硕士研究生导师,山东省优青。2006年本科毕业于郑州大学制药工程专业,获工学学士学位;2011年研究生毕业于华东理工大学药物化学专业,获医学博士学位。2012年01月至2015年06月分别在新加坡国立大学、南洋理工大学和清华大学从事博士后研究,博士及博士后期间主要从事有机小分子催化领域的研究。2015年7月受聘于青岛大学药学院,担任不对称催化与药物合成团队负责人。

迄今为止,李文军博士已在国际著名杂志Angew. Chem., Int. Ed., ACS Catal., Chem. Commun., Green Chem., Org. Lett.等发表SCI论文60余篇,其中第一作者或通讯作者50余篇,高倍引论文3篇,累计被引用1000余次,数篇被Angew. Chem., Int. Ed.Synfacts作为亮点工作被重点评述或作为封面文章被亮点介绍。授权国家发明专利四项,独立工作之前参与多项国家自然科学基金和海外基金。目前作为项目负责人主持国家自然科学基金,山东省自然科学基金和青岛大学高层次人才引进项目。

研究方向

有机合成化学:开展高选择性、高效经济、环境友好的合成方法学研究。

药物合成化学:应用有机催化的方法合成活性药物分子并进行活性研究。

过程化学:手性药物及中间体、天然药物的合成新方法研究及其过程化学开发。

发表文章:

独立工作之后:

2021

1.Ziyang Wang, Xiao Lin, Xuling Chen, Pengfei Li,*Wenjun Li*. Organocatalytic Stereoselective 1,6-Addition of Thiolacetic Acids to Alkynyl Indole Imine Methides: Access to Axially Chiral Sulfur-containing Tetrasubstituted Allenes.Org. Chem. Front.,2021,8, 3469-3474. (IF = 5.28)

2.FushuaiLi, Zhihong Yang,Yanyan Yang,Qiuhong Huang,Xuling Chen,Pengfei Li,*Mingxin Dong,*Wenjun Li*.OrganocatalyticEnantioselectiveaza-Michael Addition of Arylaminesto 7-Methide-7H-indoles.Adv. Synth. Catal.2021,363, 2557-2561. (IF = 5.85)

3.Fushuai Li, Shuai Liang,Yepeng Luan,Xuling Chen,Hanhui Zhao, Anqi Huang,Pengfei Li,*Wenjun Li*.OrganocatalyticRegio-,Diastereo- andEnantioselective γ-Additions ofIsoxazol-5(4H)-ones to β,γ-Alkynyl-α-iminoEsters for theSynthesis ofAxiallyChiralTetrasubstituted α-AminoAllenoates.Org. Chem. Front.,2021,8,1243-1248. (IF = 5.28)

2020

1.Fushuai Li, Xuling Chen,Shuai Liang, Zhenyan Shi, Pengfei Li,*Wenjun Li*.OrganocatalyticSite- andStereoselective1,6-Additions ofN-aryl-3-oxobutanamides toPropargylic aza-p-Quinone methides.Org. Chem. Front.,2020,7, 3446-3451. (IF = 5.15)

2.Qianqian Song, Pei Zhang, Shuai Liang, Xuling Chen, Pengfei Li,*Wenjun Li*.Organocatalytic Regio- and Enantioselective 1,8-Additions ofNitrogen and Sulfur Nucleophiles to 6‑Methylene‑6H‑indoles.Org. Lett.,2020,22, 7859-7863. (IF = 6.56)

3.Ziyang Wang, Anqi Huang, Fang Fang, Pengfei Li,* Guokai Liu,*Wenjun Li*.Non-hydrogenBondCatalyst-mediatedDiastereoselectiveConjugateAdditions of 5H-oxazol-4-ones too-Hydroxyphenyl-substitutedp-QuinoneMethides.Org. Biomol. Chem.,2020,18, 6807-6811. (IF = 3.49)

4.Anqi Huang, Xing Guo, Pengfei Li,*Wenjun Li*.Recent Advances in Catalytic Asymmetric Reactions ofThiazolones, Rhodanines and Their Derivatives.Adv. Synth. Catal.2020,362, 3542-3557. (IF = 5.85)

5.Xiao Lin, Fang Fang, Wei Lin, Zhantao Liu, Xiaoyong Chang, Pengfei Li,*Wenjun Li*.Organocatalytic Enantioselective α-Amination by ConjugateAddition of 5H-Thiazol-4-ones to Arylazocarboxylates: Access toChiralN,S-acetals.Asian J. Org. Chem.2020,9, 1187-1191. (IF = 3.13)

6.Chen Zhang, Yuyu Cheng, Fushuai Li, Yepeng Luan, Pengfei Li*,Wenjun Li*.Organocatalytic Enantioselective RegiodivergentC-H BondFunctionalization of 1-Naphthols with 1-Azadienes.Adv. Synth. Catal.2020,362, 1286-1291. (IF = 5.85)

2019

1.Huijun Yuan,Yao Li, Hanhui Zhao, Zhihong Yang, Xin Li*,Wenjun Li*.AsymmetricSynthesis ofAtropisomericPyrazoleviaanEnantioselectiveReaction ofAzonaphthalene withPyrazolone.Chem. Commun.,2019,55, 12715-12718.(IF =6.16)

2.Chen Zhang, Xinye Shang, Yuyu Cheng, Fushuai Li, Hanhui Zhao,Pengfei Li*,Wenjun Li*.EnantioselectiveConstruction of 3-Substituted3-amino-2-oxindolesContaining anN,N-ketalSkeleton viaOrganocatalyzedAza-addition ofIsatinImines.Org. Biomol. Chem.,2019,17,8374-8378. (IF = 3.49)

3.Lili Zhang, Yuzhe Han, Anqi Huang, Pei Zhang, Pengfei Li*,Wenjun Li*.Organocatalytic Remote Stereocontrolled 1,8-Additions ofThiazolones to Propargylic Aza‑p‑quinone Methides.Org. Lett.,2019,21, 7415-7419. (IF = 6.56)

4.Hanhui Zhao, Huijun Yuan, Yanru Zhang, Rongshi Li*,Wenjun Li*.Enamine Catalytic Annulation of Azonaphthalenes: An Access toIndole Derivatives.Org. Lett.,2019,21, 6557-6561. (IF = 6.56)

5.Yipeng Luan, Anqi Huang, Yuyu Cheng, Xiaohong Liu, Pengfei Li*,WenjunLi*.Organocatalytic Enantioselective Michael Addition ofOxazolones to 2-EnoylpyridineN-Oxides for Assembling ofPyridineN-Oxides Featuring Vicinal Oxygen-containingTetrasubstituted Stereocenters.Adv. Synth. Catal.2019,361, 4208-4214. (IF = 5.45)

6.Wei Lin, Xiao Lin, Yuyu Cheng, Xiaoyong Chang, San Zhou, Pengfei Li*,Wenjun Li*.OrganocatalyticEnantioselectiveDirectVinylogousMichaelAddition of γ-SubstitutedDeconjugateButenolides toAzadienes.Org. Chem. Front.,2019,6, 2452-2456. (IF = 5.08)

7.Pei Zhang, Qiuhong Huang, Yuyu Cheng, Rongshi Li*, Pengfei Li*,Wenjun Li*. Remote Stereocontrolled Construction of Vicinal Axially Chiral Tetrasubstituted Allenes and Heteroatom-Functionalized Quaternary Carbon Stereocenters.Org. Lett.,2019,21, 503-507. (高被引论文,IF = 6.49)

8.Pengfei Zhang, Xing Guo, Chang Liu,Wenjun Li*, Pengfei Li*. Enantioselective Construction of PyridineN-Oxides Featuring 2,3-Dihydrofuran Motifs via Phosphine-Catalyzed [4 + 1]-Annulation of 2-EnoylpyridineN-Oxides with Morita-Baylis-Hillman Carbonates.Org. Lett.,2019,21, 152-155. (IF = 6.49)

9.Anqi Huang, Lili Zhang, Dongmei Li, Yidong Liu*, Hailong Yan*,Wenjun Li*. Asymmetric One-Pot Construction of Three Stereogenic Elements: Chiral Carbon Center, Stereoisomeric Alkenes, and Chirality of Axial Styrenes.Org. Lett.,2019,21, 95-99. (IF = 6.49)

10.Wei Lin, Chen Zhang, Wen Xu, Yuyu Cheng, Pengfei Li*,Wenjun Li*.Organocatalytic Asymmetric Michael Addition of Rhodanines to Azadienes for Assembling of Sulfur-containing Tetrasubstituted Carbon Stereocenters.Adv. Synth. Catal.2019,361, 476-480. (IF = 5.12)

2018

1.Kun Liu, Xinye Shang, Yuyu Cheng, Xiaoyong Chang, Pengfei Li*,Wenjun Li*. Regioselective [3 + 2]-annulation of Hydrazonyl Chlorides with 1,3-Dicarbonyl Compounds for Assembling of Polysubstituted Pyrazoles.Org. Biomol. Chem.,2018,16, 7811-7814. (IF = 3.42)

2.Qiuhong Huang, Yuyu Cheng, Huijun Yuan, Xiaoyong Chang, Pengfei Li*,Wenjun Li*.Organocatalytic Enantioselective Mannich-Type Addition of 5H-thiazol-4-ones to Isatin-derived Imines: Access to 3-Substituted 3-amino-2-oxindoles Featured by Vicinal Sulfur-containingTetrasubstituted Stereocenters.Org. Chem. Front.,2018,5, 3226-3230. (IF = 5.45)

3.Yuyu Cheng, Zhiqiang Fang,Wenjun Li*, Pengfei Li*. Phosphine-mediated Enantioselective [4 + 1] Annulations betweenOrtho-quinone methides and Morita-Baylis-Hillman Carbonates.Org. Chem. Front.,2018,5, 2728-2733. (IF = 5.45)

4.Lili Zhang, Huijun Yuan, Wei Lin, Yuyu Cheng, Pengfei Li*,Wenjun Li*. Catalyst-Controlled Diastereodivergent Construction of Vicinal Sulfur-Functionalized Quaternary and Tertiary Stereocenters.Org. Lett.,2018,20, 4970-4974. (IF = 6.49)

5.Qiuhong Huang, Lili Zhang, Yuyu Cheng, Pengfei Li*,Wenjun Li*. Enantioselective Construction of Vicinal Sulfur-containing Tetrasubstituted Stereocenters via Organocatalyzed Mannich-Type Addition of Rhodanines to Isatin Imines.Adv. Synth. Catal.2018,360, 3266-3270. (IF = 5.12)

6.Wenjun Li*, Xianhong. Xu, Pengfei. Zhang, Pengfei Li*. Recent Advances in Catalytic Enantioselective Reactions ofpara-Quinone Methides.Chem. Asian J.2018,13, 2350-2359. (IF = 3.69)

7.Wenjun Li*, Huijun Yuan, Zhantao Liu, Zhongyin Zhang, Yuyu Cheng, Pengfei Li*. NHC-catalyzed Enantioselective [4 + 3] Cycloaddition ofortho-Hydroxyphenyl Substitutedpara-Quinone Methides with Isatin-Derived Enals.Adv. Synth. Catal.2018,360, 2460-2464. (高被引论文,IF = 5.12)

8.Wenjun Li*, Xianhong Xu, Yang Liu, Hua Gao, Yuyu Cheng, Pengfei Li*. Enantioselective Organocatalytic 1,6-Addition of Azlactones topara-Quinone Methides: An Access to α,α-Disubstituted and β,β-Diaryl-α-amino acid Esters.Org. Lett.,2018,20, 1142-1145. (高被引论文,IF = 6.49)

9.Xinye Shang, Kun Liu, Zhongyin Zhang, Xianhong Xu, Pengfei Li*,Wenjun Li*. Direct Access to Spirobiisoxazoline via the Double 1,3-Dipolar Cycloaddition of Nitrile Oxide with Allenoate.Org. Biomol. Chem.,2018,16, 895-898. (IF = 3.42)

2017

1. Huijun Yuan, Hua Gao, Kun Liu, Zhantao Liu, Jian Wang*,Wenjun Li*. Cycloadduct Formation of α,β-Unsaturated Esters with Azides Catalyzed by NHC Systems.Org. Biomol. Chem.,2017,15, 9066-9070. (IF = 3.42)

2.Lili Zhang, Yang Liu, Kun Liu, Zhantao Liu, Ningning He,Wenjun Li*. Asymmetric Synthesis of Dihydrocoumarins via the Organocatalytic Hetero-Diels-Alder Reaction ofOrtho-quinone Methides.Org. Biomol. Chem.,2017,15, 8743-8747. (IF = 3.42)

3.Lili Zhang, Xiao Zhou, Pengfei Li, Zhantao Liu, Yang Liu, Yong Sun,Wenjun Li*. Asymmetric Synthesis of Chromene Skeletons via Organocatalytic Domino Reactions ofIn situGeneratedOrtho-quinone Methide with Malononitrile and Functionalized Ketone.RSC Adv.,2017,7, 39216-39220. (IF = 2.94)

4.Huijun Yuan, Lili Zhang, Zhantao Liu, Yang Liu, Jian Wang*,Wenjun Li*. A NHC-catalyzed 1,3-Dipolar Cycloaddition Reaction of Allyl Ketones with Azides: Direct Access to 1,4,5-Trisubstituted 1,2,3-Triazoles.Org. Biomol. Chem.,2017,15, 4286-4290. (IF = 3.42)

5.Zhenyan Shi,Wenjun Li*. Enamine-Mediated 1,3-Dipolar Cycloaddition Reaction of Curcumin Derivatives with Azides: Direct Access to 1,4,5-Trisubstituted 1,2,3-Triazoles.Synthesis,2017,49, 2081-2087. (IF = 2.65)

2016

1.Wenjun Li*, Xiao Zhou, Zhenyan Shi, Yang Liu, Zhantao Liu, Hua Gao. Enolate-mediated 1,3-Dipolar Cycloaddition Reactions of Allyl Ketones with Nitrile Oxides: Direct Access to 3,5-Disubstituted Isoxazolines.Org. Biomol. Chem.,2016,14, 9985-9988. (IF = 3.42)

2.Xianhong Xu, Zhenyan Shi,Wenjun Li*. Organocatalytic 1,3-Dipolar [3+3] Cycloaddition Reaction of 1,2-Cyclohexanedione with Azides: Direct Access to Highly Substituted 1,2,3-Triazoles.New J. Chem.,2016,40, 6559-6563. (IF = 3.20)

3.Xiao Zhou, Xianhong Xu, Zhenyan Shi, Kun Liu, Hua Gao,Wenjun Li*. Enolate-mediated 1,3-Dipolar Cycloaddition Reaction of β-Functionalized Ketones with Nitrile Oxides: Direct Access to 3,4,5-Trisubstituted Isoxazoles.Org. Biomol. Chem.,2016,14, 5246-5250. (IF = 3.42)

4.Xiao Zhou, Xianhong Xu, Kun Liu, Hua Gao, Wei Wang,Wenjun Li*. Organocatalytic 1,3-Dipolar Cycloaddition Reaction of β-Keto Amides with Azides: Direct Access to 1,4,5-Trisubstituted 4-Amide-1,2,3-Triazoles.Eur. J. Org.Chem.,2016, 1886-1890. (IF = 2.88)

2015

1.Wenjun Li*, Xiao Zhou, Yepeng Luan, Jian Wang*. Direct Access to 1,4-Disubstituted 1,2,3-Triazoles through Organocatalytic 1,3-Dipolar Cycloaddition Reaction of α,β-Unsaturated Esters with Azides.RSC Adv.,2015,5, 88816-88820. (IF = 2.94)

独立工作之前:

1.Wenjun Li,Jian Wang*. Lewis Base Catalyzed Aerobic Oxidative Intermolecular Azide-Zwitterion Cycloaddition.Angew. Chem., Int. Ed.,2014,53, 14186-14190. (IF = 12.10, This work has beenhighlightedinAngew. Chem., Int. Ed.)

2.Wenjun Li, Manjaly J. Ajitha, Ming Lang, Kuo-Wei Huang, Jian Wang*. Catalytic Intermolecular Cross-Couplings of Azides and LUMO Activated Unsaturated Acyl Azoliums.ACS Catal.,2017,7, 2139-2144. (IF = 11.38)

3.Wenjun Li,Hui Liu, Xuefeng Jiang, Jian Wang*. Enantioselective Organocatalytic Conjugate Addition of Nitroalkanes to Electrophilic 2-Iminochromenes.ACS Catal.,2012,2, 1535-1538. (IF = 11.38)

4.Wenjun Li,Zhiyun Du, Jiayao Huang, Kun Zhang, Jian Wang*. Direct Access to 1,2,3-Triazoles through Organocatalytic 1,3-Dipolar Cycloaddition Reaction of Allyl Ketones with Azides.Green Chem.,2014,16, 3003-3006. (IF = 8.59)

5.Wenjun Li,Zhiyun Du, Kun Zhang, Jian Wang*. Organocatalytic 1,3-Dipolar Cycloaddition Reaction of α, β-Unsaturated Ketones with Azides through Iminium Catalysis.Green Chem.,2015,17, 781-784. (IF = 8.59)

6.Wenjun Li,Xin Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Highly Diastereo- and Enantioselective One-pot Michael-Aldol Reactions of α,β-Unsaturated Aldehydes with Imidazole Derivatives.Chem. Commun.,2011,47, 8325-8327. (IF = 6.29, This work has beenhighlightedinSynfact)

7.Wenjun Li,Qianfa Jia, Zhiyun Du, Jian Wang*. Direct Access to Triazole-olefins through Catalytic Cycloaddition of Azides to Unsaturated Aldehydes.Chem. Commun.,2013,49, 10187-10189. (IF = 6.29)

8.Wenjun Li,Qianfa Jia, Zhiyun Du, Kun Zhang, Jian Wang*.Amine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions ofAldehydes toC,N-Cyclic Azomethine Imines.Chem. Eur. J.,2014,20, 4559-4562. (IF = 5.16)

9.Wenjun Li,Jia Wei, Qianfa Jia, Zhiyun Du, Kun Zhang, Jian Wang*. Asymmetric Synthesis of Tetrahydroquinolines by [3+2] Cycloaddition Controlled by Dienamine Catalysis.Chem. Eur. J.,2014,20, 6592-6596. (IF = 5.16,Back Cover)

10.Wenjun Li,Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang, Jinxing Ye*. Catalytic Asymmetric Michael Addition with Curcumin Derivative.Org. Biomol. Chem.,2011,9, 2505-2511. (IF = 3.42)

11.Wenjun Li,Jiayao Huang, Jian Wang*. Organocatalytic Conjugate Addition Promoted by Multi-hydrogen-bond Cooperation: Access to Chiral 2-Amino-3-nitrile-chromenes.Org. Biomol. Chem.,2013,11, 400-406. (IF = 3.42)

12.Wenjun Li,Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye*. Asymmetric Direct Michael Addition of Acetophenone to α,β-Unsaturated Aldehyde.Synthesis,2011, 1085-1091. (IF = 2.65)

13.Wenjun Li,Xin Li, Tingting Ye, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric Organocatalytic Michael/α-Alkylation Reaction of α,β-Unsaturated Aldehyde with Chloroacetophenone.Tetrahedron Lett.,2011,52, 2715-2718. (IF = 2.13)

专利

1.叶金星,李文军,吴文彬,于峰,梁鑫淼,一种催化合成手性姜黄素类似物的方法。专利申请号:201110022739.9(已授权)

2.姜雪峰,汪舰,刘会,李文军,3,3-二取代-2-氧化吲哚类化合物的不对称合成方法。专利申请号:201210093045.9(已授权)

3.姜雪峰,汪舰,李一鸣,黄家尧,李文军,1,2,3,4,5,9-取代苯并吖庚因类化合物的合成方法。专利申请号:201210410905.7(已授权)

4.姜雪峰,汪舰,李一鸣,黄家尧,李文军,吡咯稠环3-吲哚酮类化合物的合成方法。专利申请号:201210413346.5(已授权)

5.李文军,石振燕,1,4,5-三取代-1,2,3-三氮唑类化合物的合成方法。专利申请号:201510913686.8

邮箱:liwj@qdu.edu.cn;联系电话:0532-83812449.

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