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李文军
发布时间:2018-10-12    作者:    点击:[]

 

李文军博士

 男,19843月出生,青岛大学特聘教授,泰山学者青年专家,硕士研究生导师,山东省优青。2006年本科毕业于郑州大学制药工程专业,获工学学士学位; 2011年研究生毕业于华东理工大学药物化学专业,获医学博士学位。 201201月至201506月分别在新加坡国立大学、南洋理工大学和清华大学从事博士后研究,博士及博士后期间主要从事有机小分子催化领域的研究。20157月受聘于青岛大学药学院,担任不对称催化与药物合成团队负责人。

 迄今为止,李文军博士已在国际著名杂志Angew. Chem., Int. Ed., ACS Catal., Chem. Commun., Green Chem., Org. Lett.等发表SCI论文50余篇,其中第一作者或通讯作者40余篇,高倍引论文3篇,累计被引用1000余次,数篇被Angew. Chem., Int. Ed.Synfacts作为亮点工作被重点评述或作为封面文章被亮点介绍。授权国家发明专利四项,独立工作之前参与多项国家自然科学基金、中组部青年千人项目基金和海外基金。目前作为项目负责人主持国家自然科学基金,山东省自然科学基金和青岛大学高层次人才引进项目。

 

Ø 研究方向

有机合成化学:开展高选择性、高效经济、环境友好的合成方法学研究。

药物合成化学:应用有机催化的方法合成活性药物分子并进行活性研究。

过程化学:手性药物及中间体、天然药物的合成新方法研究及其过程化学开发。

 

Ø 发表文章:

独立工作之后:

1. Chen Zhang, Yuyu Cheng, Fushuai Li, Yepeng Luan, Pengfei Li*, Wenjun Li*. Organocatalytic Enantioselective Regiodivergent C-H Bond Functionalization of 1-Naphthols with 1-Azadienes. Adv. Synth. Catal. 2020, 362, 1286-1291. (IF = 5.45)

2. Huijun Yuan, Yao Li, Hanhui Zhao, Zhihong Yang, Xin Li*, Wenjun Li*. Asymmetric Synthesis of Atropisomeric Pyrazole via an Enantioselective Reaction of Azonaphthalene with Pyrazolone. Chem. Commun., 2019, 55, 12715-12718. (IF = 6.16)

3. Chen Zhang, Xinye Shang, Yuyu Cheng, Fushuai Li, Hanhui Zhao, Pengfei Li*,  Wenjun Li*. Enantioselective Construction of 3-Substituted 3-amino-2-oxindoles Containing an N,N-ketal Skeleton via Organocatalyzed Aza-addition of Isatin Imines. Org. Biomol. Chem., 2019, 17, 8374-8378. (IF = 3.49)

4. Lili Zhang, Yuzhe Han, Anqi Huang, Pei Zhang, Pengfei Li*, Wenjun Li*. Organocatalytic Remote Stereocontrolled 1,8-Additions of Thiazolones to Propargylic Azapquinone Methides. Org. Lett., 2019, 21, 7415-7419. (IF = 6.56)

5. Hanhui Zhao, Huijun Yuan, Yanru Zhang, Rongshi Li*, Wenjun Li*. Enamine Catalytic Annulation of Azonaphthalenes: An Access to Indole Derivatives. Org. Lett., 2019, 21, 6557-6561. (IF = 6.56)

6. Yipeng Luan, Anqi Huang, Yuyu Cheng, Xiaohong Liu, Pengfei Li*, Wenjun Li*. Organocatalytic Enantioselective Michael Addition of Oxazolones to 2-Enoylpyridine N-Oxides for Assembling of Pyridine N-Oxides Featuring Vicinal Oxygen-containing Tetrasubstituted Stereocenters. Adv. Synth. Catal. 2019, 361, 4208-4214. (IF = 5.45)

7. Wei Lin, Xiao Lin, Yuyu Cheng, Xiaoyong Chang, San Zhou, Pengfei Li*,  Wenjun Li*. Organocatalytic Enantioselective Direct Vinylogous Michael Addition of γ-Substituted Deconjugate Butenolides to Azadienes. Org. Chem. Front., 2019, 6, 2452-2456. (IF = 5.08)

8. Pei Zhang, Qiuhong Huang, Yuyu Cheng, Rongshi Li*, Pengfei Li*, Wenjun Li*. Remote Stereocontrolled Construction of Vicinal Axially Chiral Tetrasubstituted Allenes and Heteroatom-Functionalized Quaternary Carbon Stereocenters. Org. Lett., 2019, 21, 503-507. (高被引论文, IF = 6.49)

9. Pengfei Zhang, Xing Guo, Chang Liu, Wenjun Li*, Pengfei Li*. Enantioselective Construction of Pyridine N-Oxides Featuring 2,3-Dihydrofuran Motifs via Phosphine-Catalyzed [4 + 1]-Annulation of 2-Enoylpyridine N-Oxides with Morita-Baylis-Hillman Carbonates. Org. Lett., 2019, 21, 152-155. (IF = 6.49)

10. Anqi Huang, Lili Zhang, Dongmei Li, Yidong Liu*, Hailong Yan*, Wenjun Li*. Asymmetric One-Pot Construction of Three Stereogenic Elements: Chiral Carbon Center, Stereoisomeric Alkenes, and Chirality of Axial Styrenes. Org. Lett., 2019, 21, 95-99. (IF = 6.49)

11. Wei Lin, Chen Zhang, Wen Xu, Yuyu Cheng, Pengfei Li*, Wenjun Li*. Organocatalytic Asymmetric Michael Addition of Rhodanines to Azadienes for Assembling of Sulfur-containing Tetrasubstituted Carbon Stereocenters. Adv. Synth. Catal. 2019, 361, 476-480. (IF = 5.12)

12. Kun Liu, Xinye Shang, Yuyu Cheng, Xiaoyong Chang, Pengfei Li*, Wenjun Li*. Regioselective [3 + 2]-annulation of Hydrazonyl Chlorides with 1,3-Dicarbonyl Compounds for Assembling of Polysubstituted Pyrazoles. Org. Biomol. Chem., 2018, 16, 7811-7814. (IF = 3.42)

13. Qiuhong Huang, Yuyu Cheng, Huijun Yuan, Xiaoyong Chang, Pengfei Li*, Wenjun Li*. Organocatalytic Enantioselective Mannich-Type Addition of 5H-thiazol-4-ones to Isatin-derived Imines: Access to 3-Substituted 3-amino-2-oxindoles Featured by Vicinal Sulfur-containing Tetrasubstituted Stereocenters. Org. Chem. Front., 2018, 5, 3226-3230. (IF = 5.45)

14. Yuyu Cheng, Zhiqiang Fang, Wenjun Li*,  Pengfei Li*. Phosphine-mediated Enantioselective [4 + 1] Annulations between Ortho-quinone methides and Morita-Baylis-Hillman Carbonates. Org. Chem. Front., 2018, 5, 2728-2733. (IF = 5.45)

15. Lili Zhang, Huijun Yuan, Wei Lin, Yuyu Cheng, Pengfei Li*, Wenjun Li*. Catalyst-Controlled Diastereodivergent Construction of Vicinal Sulfur-Functionalized Quaternary and Tertiary Stereocenters. Org. Lett., 2018, 20, 4970-4974. (IF = 6.49)

16. Qiuhong Huang, Lili Zhang, Yuyu Cheng, Pengfei Li*, Wenjun Li*. Enantioselective Construction of Vicinal Sulfur-containing Tetrasubstituted Stereocenters via Organocatalyzed Mannich-Type Addition of Rhodanines to Isatin Imines. Adv. Synth. Catal. 2018, 360, 3266-3270. (IF = 5.12)

17. Wenjun Li*, Xianhong. Xu, Pengfei. Zhang, Pengfei Li*. Recent Advances in Catalytic Enantioselective Reactions of para-Quinone Methides. Chem. Asian J. 2018, 13, 2350-2359. (IF = 3.69)

18. Wenjun Li*, Huijun Yuan, Zhantao Liu, Zhongyin Zhang, Yuyu Cheng, Pengfei Li*. NHC-catalyzed Enantioselective [4 + 3] Cycloaddition of ortho-Hydroxyphenyl Substituted para-Quinone Methides with Isatin-Derived Enals. Adv. Synth. Catal. 2018, 360, 2460-2464. (高被引论文, IF = 5.12)

19. Wenjun Li*, Xianhong Xu, Yang Liu, Hua Gao, Yuyu Cheng, Pengfei Li*. Enantioselective Organocatalytic 1,6-Addition of Azlactones to para-Quinone Methides: An Access to α,α-Disubstituted and β,β-Diaryl-α-amino acid Esters. Org. Lett., 2018, 20, 1142-1145. (高被引论文, IF = 6.49)

20. Xinye Shang, Kun Liu, Zhongyin Zhang, Xianhong Xu, Pengfei Li*, Wenjun Li*. Direct Access to Spirobiisoxazoline via the Double 1,3-Dipolar Cycloaddition of Nitrile Oxide with Allenoate. Org. Biomol. Chem., 2018, 16, 895-898. (IF = 3.42)

21. Huijun Yuan, Hua Gao, Kun Liu, Zhantao Liu, Jian Wang*, Wenjun Li*. Cycloadduct Formation of α,β-Unsaturated Esters with Azides Catalyzed by NHC Systems. Org. Biomol. Chem., 2017, 15, 9066-9070. (IF = 3.42)

22. Lili Zhang, Yang Liu, Kun Liu, Zhantao Liu, Ningning He, Wenjun Li*. Asymmetric Synthesis of Dihydrocoumarins via the Organocatalytic Hetero-Diels-Alder Reaction of Ortho-quinone Methides. Org. Biomol. Chem., 2017, 15, 8743-8747. (IF = 3.42)

23. Lili Zhang, Xiao Zhou, Pengfei Li, Zhantao Liu, Yang Liu, Yong Sun, Wenjun Li*. Asymmetric Synthesis of Chromene Skeletons via Organocatalytic Domino Reactions of In situ Generated Ortho-quinone Methide with Malononitrile and Functionalized Ketone. RSC Adv., 2017, 7, 39216-39220. (IF = 2.94)

24. Huijun Yuan, Lili Zhang, Zhantao Liu, Yang Liu, Jian Wang*, Wenjun Li*. A NHC-catalyzed 1,3-Dipolar Cycloaddition Reaction of Allyl Ketones with Azides: Direct Access to 1,4,5-Trisubstituted 1,2,3-Triazoles. Org. Biomol. Chem., 2017, 15, 4286-4290. (IF = 3.42)

25. Zhenyan Shi, Wenjun Li*. Enamine-Mediated 1,3-Dipolar Cycloaddition Reaction of Curcumin Derivatives with Azides: Direct Access to 1,4,5-Trisubstituted 1,2,3-Triazoles. Synthesis, 2017, 49, 2081-2087. (IF = 2.65)

26. Wenjun Li*, Xiao Zhou, Zhenyan Shi, Yang Liu, Zhantao Liu, Hua Gao. Enolate-mediated 1,3-Dipolar Cycloaddition Reactions of Allyl Ketones with Nitrile Oxides: Direct Access to 3,5-Disubstituted Isoxazolines. Org. Biomol. Chem., 2016, 14, 9985-9988. (IF = 3.42)

27. Xianhong Xu, Zhenyan Shi, Wenjun Li*. Organocatalytic 1,3-Dipolar [3+3] Cycloaddition Reaction of 1,2-Cyclohexanedione with Azides: Direct Access to Highly Substituted 1,2,3-Triazoles. New J. Chem., 2016, 40, 6559-6563. (IF = 3.20)

28. Xiao Zhou, Xianhong Xu, Zhenyan Shi, Kun Liu, Hua Gao, Wenjun Li*. Enolate-mediated 1,3-Dipolar Cycloaddition Reaction of β-Functionalized Ketones with Nitrile Oxides: Direct Access to 3,4,5-Trisubstituted Isoxazoles. Org. Biomol. Chem., 2016, 14, 5246-5250. (IF = 3.42)

29. Xiao Zhou, Xianhong Xu, Kun Liu, Hua Gao, Wei Wang, Wenjun Li*. Organocatalytic 1,3-Dipolar Cycloaddition Reaction of β-Keto Amides with Azides: Direct Access to 1,4,5-Trisubstituted 4-Amide-1,2,3-Triazoles. Eur. J. Org.Chem., 2016, 1886-1890. (IF = 2.88)

30. Wenjun Li*, Xiao Zhou, Yepeng Luan, Jian Wang*. Direct Access to 1,4-Disubstituted 1,2,3-Triazoles through Organocatalytic 1,3-Dipolar Cycloaddition Reaction of α,β-Unsaturated Esters with Azides. RSC Adv., 2015, 5, 88816-88820. (IF = 2.94)

独立工作之前:

1. Wenjun Li, Jian Wang*. Lewis Base Catalyzed Aerobic Oxidative Intermolecular Azide-Zwitterion Cycloaddition. Angew. Chem., Int. Ed., 2014, 53, 14186-14190. (IF = 12.10, This work has been highlighted in Angew. Chem., Int. Ed.)

2. Wenjun Li, Manjaly J. Ajitha, Ming Lang, Kuo-Wei Huang, Jian Wang*. Catalytic Intermolecular Cross-Couplings of Azides and LUMO Activated Unsaturated Acyl Azoliums. ACS Catal., 2017, 7, 2139-2144. (IF = 11.38)

3. Wenjun Li, Hui Liu, Xuefeng Jiang, Jian Wang*. Enantioselective Organocatalytic Conjugate Addition of Nitroalkanes to Electrophilic 2-Iminochromenes. ACS Catal., 2012, 2, 1535-1538. (IF = 11.38)

4. Wenjun Li, Zhiyun Du, Jiayao Huang, Kun Zhang, Jian Wang*. Direct Access to 1,2,3-Triazoles through Organocatalytic 1,3-Dipolar Cycloaddition Reaction of Allyl Ketones with Azides. Green Chem., 2014, 16, 3003-3006. (IF = 8.59)

5. Wenjun Li, Zhiyun Du, Kun Zhang, Jian Wang*. Organocatalytic 1,3-Dipolar Cycloaddition Reaction of α, β-Unsaturated Ketones with Azides through Iminium Catalysis. Green Chem., 2015, 17, 781-784. (IF = 8.59)

6. Wenjun Li, Xin Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Highly Diastereo- and Enantioselective One-pot Michael-Aldol Reactions of α,β-Unsaturated Aldehydes with Imidazole Derivatives. Chem. Commun., 2011, 47, 8325-8327. (IF = 6.29, This work has been highlighted in Synfact)

7. Wenjun Li, Qianfa Jia, Zhiyun Du, Jian Wang*. Direct Access to Triazole-olefins through Catalytic Cycloaddition of Azides to Unsaturated Aldehydes. Chem. Commun., 2013, 49, 10187-10189. (IF = 6.29)

8. Wenjun Li, Qianfa Jia, Zhiyun Du, Kun Zhang, Jian Wang*. Amine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions of Aldehydes to C,N-Cyclic Azomethine Imines. Chem. Eur. J., 2014, 20, 4559-4562. (IF = 5.16)

9. Wenjun Li, Jia Wei, Qianfa Jia, Zhiyun Du, Kun Zhang, Jian Wang*. Asymmetric Synthesis of Tetrahydroquinolines by [3+2] Cycloaddition Controlled by Dienamine Catalysis. Chem. Eur. J., 2014, 20, 6592-6596. (IF = 5.16, Back Cover)

10. Wenjun Li, Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang, Jinxing Ye*. Catalytic Asymmetric Michael Addition with Curcumin Derivative. Org. Biomol. Chem., 2011, 9, 2505-2511. (IF = 3.42)

11. Wenjun Li, Jiayao Huang, Jian Wang*. Organocatalytic Conjugate Addition Promoted by Multi-hydrogen-bond Cooperation: Access to Chiral 2-Amino-3-nitrile-chromenes. Org. Biomol. Chem., 2013, 11, 400-406. (IF = 3.42)

12. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye*. Asymmetric Direct Michael Addition of Acetophenone to α,β-Unsaturated Aldehyde. Synthesis, 2011, 1085-1091. (IF = 2.65)

13. Wenjun Li, Xin Li, Tingting Ye, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric Organocatalytic Michael/α-Alkylation Reaction of α,β-Unsaturated Aldehyde with Chloroacetophenone. Tetrahedron Lett., 2011, 52, 2715-2718. (IF = 2.13)

14. Woon-Yew Siau, Wenjun Li, Fei Xue, Qiao Ren, Minghu Wu, Shaofa Sun, Haibing Guo, Xuefeng Jiang, Jian Wang*. Catalytic Enantioselective α-Functionalization of Oxindoles through Oxidative Reactions with Naphthoquinones. Chem. Eur. J., 2012, 18, 9491-9495. (IF = 5.16)

15. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye*. Enantioselective Michael Reaction of α-Alkyl-β-keto Esters and Enones under Multifunctional Catalysis. Org. Lett., 2010, 12, 5218-5221. (IF = 6.49)

16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang, Jinxing Ye*. Asymmetric Organocatalytic Michael Addition of Anthrone to Enone. Org. Biomol. Chem., 2010, 8, 3244-3250. (IF = 3.42)

17. Zhichao Jin, Huicai Huang, Wenjun Li, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye*. Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through a One-pot Cascade Reaction. Adv. Synth. Catal., 2011, 353, 343-348. (IF = 5.12)

18. Yufeng Zhou, Xin Li, Wenjun Li, Chunlin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric Organocatalytic Michael Addition of α,β-Unsaturated Ketone with 1,2,4-Triazole. Synlett, 2010, 15, 2357-2360. (IF = 2.37)

19. Qiao Ren, Tao Gao, Wenjun Li, Li Wan, Yimin Hu, Yanhong Peng, Shaofa Sun, Liqing Hu, Minghu Wu, Haibing, Guo, Jian Wang*. A Highly Enantioselective Michael Reaction between α,β-Unsaturated Ketones and Malonic Acid Half-thioesters. New J. Chem., 2015, 39, 5100-5103. (IF = 3.20)

20. Qiao Ren, Shaofa Sun, Jiayao Huang, Wenjun Li, Minghu Wu, Haibing Guo, Jian Wang*. Enantioselective Cascade Reaction between α,β-Unsaturated Aldehydes and Malonic Half-thioesters: Rapid Access to Chiral δ-Lactones. Chem. Commun., 2014, 50, 6137-6140. (IF = 6.29)

21. Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric Vinylogous Michael Reaction of α,β-Unsaturated Ketones with γ-Butenolide under Multifunctional Catalysis. Chem. Commun., 2010, 46, 5957-5959. (IF = 6.29)

22. Qiao Ren, Jiayao Huang, Lei Wang, Wenjun Li, Hui Liu, Xuefeng Jiang, Jian Wang*. Highly Efficient Assembly of 3-Hydroxy Oxindole Scaffold via a Catalytic Decarboxylative [1,2]-Addition Strategy. ACS Catal., 2012, 2, 2622-2625. (IF = 11.38)

 

Ø 专利

1. 叶金星,李文军,吴文彬,于峰,梁鑫淼,一种催化合成手性姜黄素类似物的方法。专利申请号:201110022739.9(已授权)

2. 姜雪峰,汪舰,刘会,李文军,3,3-二取代-2-氧化吲哚类化合物的不对称合成方法。专利申请号:201210093045.9(已授权)

3. 姜雪峰,汪舰,李一鸣,黄家尧,李文军,1,2,3,4,5,9-取代苯并吖庚因类化合物的合成方法。专利申请号:201210410905.7(已授权)

4. 姜雪峰,汪舰,李一鸣,黄家尧,李文军,吡咯稠环3-吲哚酮类化合物的合成方法。专利申请号:201210413346.5(已授权)

5. 李文军,石振燕,1,4,5-三取代-1,2,3-三氮唑类化合物的合成方法。专利申请号:201510913686.8

 

邮箱:liwj@qdu.edu.cn;  联系电话:0532-83812449.

 

 

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